Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.812


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX3chr5_+_170668892-0.476.3e-02Click!
TLX1chr10_+_102881050-0.457.8e-02Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_102340579 11.319 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr7_+_115952279 8.940 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr7_+_115952325 8.499 CAV1
caveolin 1, caveolae protein, 22kDa
chr7_+_115952074 8.471 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr12_+_13240868 7.367 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240987 6.807 EMP1
epithelial membrane protein 1
chr1_-_171441234 6.192 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr14_+_85066207 6.142 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_-_54392328 6.102 NM_001144997
ITGA7
integrin, alpha 7
chr21_+_45699830 6.027 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr2_-_218551786 5.783 TNS1
tensin 1
chr8_-_42184194 5.733 PLAT
plasminogen activator, tissue
chr8_-_42184350 5.583 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr15_-_32875040 5.575 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr16_+_69060325 5.482 FUK
fucokinase
chr17_-_74433048 5.336 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chrX_+_99785818 5.247 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr17_-_74432800 4.966 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_74432671 4.800 TIMP2
TIMP metallopeptidase inhibitor 2
chr12_+_64504408 4.714 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr3_-_31997738 4.394 OSBPL10
oxysterol binding protein-like 10
chr11_+_113671744 4.361 NM_006169
NNMT
nicotinamide N-methyltransferase
chr17_-_74487527 4.224 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr5_-_111120817 4.102 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr9_+_115396020 4.036 NM_144489
RGS3
regulator of G-protein signaling 3
chr14_+_85066265 3.850 FLRT2
fibronectin leucine rich transmembrane protein 2
chr8_-_27524744 3.841 NM_203339
CLU
clusterin
chr5_-_111120929 3.832 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr1_+_149779384 3.750 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr10_+_17311347 3.720 VIM
vimentin
chrX_+_102518064 3.655 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr1_+_201862548 3.516 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr6_+_132170888 3.501 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr10_+_17311242 3.496 VIM
vimentin
chr10_+_17311307 3.449 VIM
vimentin
chr2_-_217268492 3.446 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr5_-_111121150 3.444 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr5_-_111120764 3.414 C5orf13
chromosome 5 open reading frame 13
chr9_-_78710698 3.371 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr8_-_27525084 3.363 NM_001171138
CLU
clusterin
chr10_+_17312654 3.318 VIM
vimentin
chr9_-_129656778 3.297 ENG
endoglin
chr3_+_8750485 3.293 NM_033337
NM_001234
CAV3

caveolin 3

chr10_+_17311283 3.274 VIM
vimentin
chr7_+_100557098 3.250 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr10_+_17311282 3.216 VIM
vimentin
chr1_-_151867338 3.216 NM_005979
S100A13
S100 calcium binding protein A13
chr9_-_129656581 3.207 ENG
endoglin
chr20_+_8997660 3.188 NM_001172646
PLCB4
phospholipase C, beta 4
chr8_-_18585721 3.174 PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_151866593 3.153 NM_001024211
S100A13
S100 calcium binding protein A13
chrX_+_102517909 3.051 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr7_+_142789476 2.921 ZYX
zyxin
chr2_-_192420168 2.907 NM_004657
SDPR
serum deprivation response
chrX_+_99786044 2.890 SRPX2
sushi-repeat containing protein, X-linked 2
chr12_+_118100977 2.833 NM_014365
HSPB8
heat shock 22kDa protein 8
chr21_-_27139563 2.832 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_-_53099203 2.790 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_2116048 2.752 IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_+_142788730 2.717 ZYX
zyxin
chr20_+_33223434 2.680 NM_006404
PROCR
protein C receptor, endothelial
chr2_-_192419896 2.677 SDPR
serum deprivation response
chr4_+_38545741 2.648 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr9_+_123083540 2.623 GSN
gelsolin
chr21_-_27139143 2.610 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr7_+_22733626 2.523 IL6
interleukin 6 (interferon, beta 2)
chr15_-_88148538 2.483 ANPEP
alanyl (membrane) aminopeptidase
chr9_-_129656413 2.471 ENG
endoglin
chr5_-_172130766 2.455 NM_004417
DUSP1
dual specificity phosphatase 1
chr9_-_129656830 2.436 NM_000118
NM_001114753
ENG

endoglin

chr10_+_17310475 2.413 VIM
vimentin
chr9_+_138991835 2.410 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr11_-_6298284 2.406 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chrX_-_13866451 2.377 GPM6B
glycoprotein M6B
chr5_-_73973004 2.372 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr12_-_53099269 2.349 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr11_-_65082705 2.307 LTBP3
latent transforming growth factor beta binding protein 3
chr15_-_75150177 2.289 TSPAN3
tetraspanin 3
chr10_+_17311788 2.247 VIM
vimentin
chr9_+_138991775 2.246 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr3_-_150903749 2.204 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr2_-_37752731 2.192 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr20_+_43952997 2.178 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr1_-_241485298 2.177 NM_001042404
NM_001042405
NM_014812
CEP170


centrosomal protein 170kDa


chr15_-_88148177 2.110 ANPEP
alanyl (membrane) aminopeptidase
chr2_-_24161033 2.105 NM_147184
NM_004881
TP53I3

tumor protein p53 inducible protein 3

chr7_-_151205142 2.088 NM_016203
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr16_+_31391998 2.055 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr5_-_16989371 2.019 NM_012334
MYO10
myosin X
chr22_-_37970902 2.019 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr7_+_22733290 2.009 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr3_-_31998241 1.993 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr10_+_124310170 1.991 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr2_-_216008689 1.987 FN1
fibronectin 1
chr8_-_13018123 1.945 NM_001164271
DLC1
deleted in liver cancer 1
chr1_-_199608941 1.899 TNNT2
troponin T type 2 (cardiac)
chr20_-_23566325 1.883 NM_000099
CST3
cystatin C
chr17_+_4795128 1.851 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr6_-_47030492 1.836 NM_015234
GPR116
G protein-coupled receptor 116
chr1_-_151866367 1.829 NM_001024212
S100A13
S100 calcium binding protein A13
chr15_-_88159061 1.821 NM_001150
ANPEP
alanyl (membrane) aminopeptidase
chr13_+_97593469 1.802 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr1_-_151804929 1.770 NM_005978
S100A2
S100 calcium binding protein A2
chr6_+_132170847 1.732 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chrX_+_153767803 1.718 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr3_-_52463070 1.700 NM_003280
TNNC1
troponin C type 1 (slow)
chr2_+_108604111 1.694 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr9_-_112840064 1.678 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr1_+_201862552 1.665 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr1_+_67168470 1.642 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chrX_-_154341451 1.639 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr8_-_13178399 1.634 DLC1
deleted in liver cancer 1
chr9_-_23811842 1.627 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr8_-_82557956 1.615 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr9_-_23811808 1.612 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr10_+_17311962 1.607 VIM
vimentin
chr22_+_31526801 1.599 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr12_-_8706637 1.592 NM_003480
MFAP5
microfibrillar associated protein 5
chr13_+_97593411 1.580 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr17_-_77394872 1.574 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr2_+_66516020 1.555 NM_002398
MEIS1
Meis homeobox 1
chr2_-_37752272 1.521 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr12_-_8706746 1.506 MFAP5
microfibrillar associated protein 5
chrX_+_154264931 1.506 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated (intronic transcript) 2
coagulation factor VIII-associated (intronic transcript) 3
coagulation factor VIII-associated (intronic transcript) 1
chr12_-_53099277 1.506 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_8706533 1.502 MFAP5
microfibrillar associated protein 5
chr15_-_38000379 1.481 NM_007223
GPR176
G protein-coupled receptor 176
chr6_+_39868770 1.454 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr17_+_24394281 1.451 PIPOX
pipecolic acid oxidase
chr19_+_45563637 1.435 PLD3
phospholipase D family, member 3
chr1_+_26480134 1.431 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr1_-_227636462 1.420 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr20_-_60375695 1.418 NM_005560
LAMA5
laminin, alpha 5
chr14_+_23937766 1.393 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chrX_+_133952633 1.380 NM_001163438
LOC644538
hypothetical protein LOC644538
chr5_-_54317102 1.357 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr7_+_115953582 1.332 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr2_+_66516196 1.320 MEIS1
Meis homeobox 1
chr5_+_150000394 1.306 NM_001109974
NM_007286
SYNPO

synaptopodin

chr12_-_54408391 1.290 CD63
CD63 molecule
chr8_+_55533047 1.266 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr19_+_45563603 1.253 PLD3
phospholipase D family, member 3
chr16_-_28457825 1.237 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr9_-_129679760 1.207 NM_000476
AK1
adenylate kinase 1
chr17_+_54997667 1.195 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr19_+_45563594 1.190 PLD3
phospholipase D family, member 3
chr4_+_124540114 1.183 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr19_+_45563607 1.162 PLD3
phospholipase D family, member 3
chr16_+_56219802 1.137 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chrX_-_13866565 1.113 NM_001001994
GPM6B
glycoprotein M6B
chr1_+_201862845 1.108 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr13_-_95503566 1.105 NM_020121
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr10_-_128067062 1.104 NM_003474
NM_021641
ADAM12

ADAM metallopeptidase domain 12

chr19_+_16039170 1.099 NM_001145160
TPM4
tropomyosin 4
chr8_+_26491317 1.097 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr15_-_57452345 1.088 MYO1E
myosin IE
chr17_-_59817722 1.070 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr11_+_32068990 1.068 NM_002901
RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr8_+_22078589 1.062 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr1_+_160868932 1.060 DDR2
discoidin domain receptor tyrosine kinase 2
chr5_+_66160359 1.052 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr3_+_35656012 1.047 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr16_-_19803606 1.015 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chrX_+_54852217 1.004 NM_201222
MAGED2
melanoma antigen family D, 2
chr7_+_75770801 0.999 HSPB1
heat shock 27kDa protein 1
chr8_+_26491383 0.995 DPYSL2
dihydropyrimidinase-like 2
chr3_+_129253977 0.991 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr10_-_126839546 0.979 NM_001083914
CTBP2
C-terminal binding protein 2
chrX_+_149364377 0.937 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr8_-_62789483 0.936 ASPH
aspartate beta-hydroxylase
chrX_-_13866366 0.929


chr17_+_24394043 0.928 NM_016518
PIPOX
pipecolic acid oxidase
chr1_+_160868822 0.920 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr17_-_15104768 0.914 NM_153322
PMP22
peripheral myelin protein 22
chr1_-_20685314 0.910 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr3_-_150578148 0.905 TM4SF1
transmembrane 4 L six family member 1
chr14_-_50068928 0.883 NM_006575
NM_198794
MAP4K5

mitogen-activated protein kinase kinase kinase kinase 5

chr13_+_112670757 0.881 NM_001112732
MCF2L
MCF.2 cell line derived transforming sequence-like
chr12_+_55808514 0.879 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr15_-_88150823 0.874 ANPEP
alanyl (membrane) aminopeptidase
chr9_+_123070191 0.869 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr11_-_65082208 0.851 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr19_+_60838170 0.851


chr9_+_123070234 0.848 GSN
gelsolin
chr7_+_93977267 0.845 CASD1
CAS1 domain containing 1
chr2_-_46996443 0.843 MCFD2
multiple coagulation factor deficiency 2
chr7_+_75770928 0.833 HSPB1
heat shock 27kDa protein 1
chr9_-_23811477 0.828 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr2_-_46996754 0.825 NM_001171507
NM_001171510
MCFD2

multiple coagulation factor deficiency 2

chr8_-_62764839 0.791 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr22_-_22970850 0.780 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr13_-_49057629 0.777 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr7_-_81237162 0.765 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr9_-_112840801 0.762 LPAR1
lysophosphatidic acid receptor 1
chr9_+_123070276 0.756 GSN
gelsolin
chr2_+_10360471 0.744 NM_002149
HPCAL1
hippocalcin-like 1
chr3_-_33235710 0.733 NM_015551
SUSD5
sushi domain containing 5
chr15_-_57452361 0.724 NM_004998
MYO1E
myosin IE
chr1_-_115102124 0.706 CSDE1
cold shock domain containing E1, RNA-binding
chr12_+_103204842 0.704 NM_003330
NM_182729
NM_182742
NM_182743
TXNRD1



thioredoxin reductase 1




Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.68 4.59e-03 GO:0044421 extracellular region part
1.45 2.61e-02 GO:0005576 extracellular region
1.67 4.17e-02 GO:0005615 extracellular space
2.02 4.56e-02 GO:0009986 cell surface

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.38 4.27e-02 GO:0046982 protein heterodimerization activity
5.93 4.78e-02 GO:0008060 ARF GTPase activator activity